Biomedical Assessment Of Copper Nanoparticles On Anti-Diabetic, Anti-Inflammatory, And Antioxidant Properties

Abstract

Metal oxide nanoparticles synthesized using green chemistry have recently gained attention for their improved bioactivity and reduced environmental impact. Due to the high concentration of phytochemicals in the medicinal plant Alpinia officinarum, researchers have looked at the possibility of biosynthesising CuNPs using this plant. Inflammation, cytotoxicity, along with diabetes are the subjects of this investigation into the health impacts of Alpinia officinarum CuNPs and extract from Alpinia officinarum rhizomes. The brine shrimp lethality experiments revealed a 20% mortality rate at 80 µL as a result of dose-dependent cytotoxicity. At 80 µg/mL, CuNPs inhibited α-amylase and α-glucosidase enzymes, which had a notable impact on postprandial hyperglycemia management (82%). Both the plant extract and the CuNPs showed anti-inflammatory effect in comparative evaluations utilizing Bovine Serum Albumin and Egg Albumin tests; however, the standard showed significantly greater efficacy. The observed bioactivities were probably amplified by the synergistic effects of phytochemicals such as flavonoids, polyphenols, and others. Results provide support to the idea that Alpinia officinarum-derived Cu nanoparticles have multiple biological uses, including metabolic process and inflammatory disease prevention and treatment.