Biological Properties Of Blumea Balsamifera Using Silver Nanoparticles (Agnps)

Abstract

In the field of biomedical and pharmaceutical sciences, nanotechnology has become a game-changer, especially for the creation of long-term, environmentally safe medicines.  Using Blumea balsamifera as a biogenic source for synthesising AgNPs, this research investigates the biological characteristics of the plant.  The anti-inflammatory, antibacterial, antioxidant, and wound-healing characteristics of the famous medicinal plant Blumea balsamifera have made it a mainstay in traditional medicine throughout Asia.  In this work, we used a green synthesis process that is both cost-effective and ecologically friendly. We formed AgNPs utilising the aqueous leaf extract of B. balsamifera as a reducing and stabilising agent. The AgNPs that were synthesised were extensively studied utilising various analytical methods.  The creation of AgNPs was verified by surface plasmon resonance, which was detected by UV-Visible spectroscopy.  Functional groups involved in stabilising nanoparticles were discovered by use of Fourier-transform infrared spectroscopy (FTIR).  Scanning electron microscopy (SEM) revealed details on the shape and size distribution of the AgNPs, which usually vary from 20 to 50 nm, while X-ray diffraction (XRD) research validated their crystalline nature. Biosynthesised AgNPs were compared to a crude Blumea balsamifera extract in a comprehensive evaluation of their biological activity.  The agar well diffusion technique was used to assess the antibacterial activity of the AgNPs against a panel of pathogenic gram-positive and gram-negative bacterial strains. The results showed that the AgNPs had much greater zones of inhibition.  Because of the synergistic effects of silver ions and phytochemicals, AgNPs demonstrated improved activity in the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging test, which was used to evaluate antioxidant capacity.  Also, the MTT test was used to study cytotoxicity on certain mammalian cell lines; the results showed effects that were dose-dependent and that there was a good compromise between bioactivity and biocompatibility.

 In conclusion, this study's results highlight the significant improvement in biological properties after nanoparticle synthesis, making AgNPs mediated by Blumea balsamifera promising candidates for use in antimicrobial formulations, antioxidant treatments, and other biomedical interventions in the future.  The findings strongly support the idea that plant-mediated nanoparticle production might serve as a foundation for environmentally friendly nanomedicine and holistic healthcare solutions.