Design, Synthesis And Antitubercular Activity Assessment Of Some 5-Methoxypyrazine-2-Carboxamide Derivatives

Abstract

Seven new compounds having 5-methoxypyrazine-2-carboxamide nucleus were synthesized. The chemical structures of the newly synthesized 5-methoxypyrazine-2-carboxamide derivatives were verified by analytical data. Additionally, the resazurin assay was used to assess the antitubercular activity of all the newly synthesized compounds against M. tuberculosis H37RV. The obtained results were compared with Rifampicin, Isoniazid and Pyrazinamide. On M. tuberculosis H37RV, the plurality of the tested compounds displayed impressive antitubercular efficacy. Two of these compounds, S7-13 and S7-26, showed stronger antitubercular activity than pyrazinamide (MIC 12.5 micrograms per milliliter), their MIC values were found 1.6 and 6.25 micrograms per millilitre, respectively.