Determine The Immunological Parameters Of The Torque Teno Virus Among Blood Donors In Iraq / Mosul City

Abstract

Background Blood transfusions are one of the most common ways viruses are transmitted .‏Torque Teno Virus (TTV) is) is a member of the Anelloviridae family globally prevalent virus in humans, yet comprehensive knowledge about its prevalence, predominant transmission routes, and pathogenesis remains limited. TTV has an extremely high prevalence and is regarded as a part of the human virome, the replication of which is controlled by a functioning immune system. The viral load of TTV in the plasma of individuals is thought to reflect the degree of immunosuppression. Measuring and quantifying this viral load is especially promising in organ transplantation, as many studies have shown a strong correlation between high TTV loads and an increased risk of infection on one side, and low TTV loads and an increased risk of rejection on the other side. This study aims to detect this virus in blood donors of various age groups using the polymerase chain reaction (PCR) technique Methods One hundred and fifty blood samples were collected from male donors of various ages, between November 2024 and April 2025, at the General Blood Bank of Al-Jumhuri Hospital in Mosul, Iraq. All genes were characterized using polymerase chain reaction (PCR). Results: Positive results were 9.3% of all samples. The prevalence of TTV was as high as 21.4% in people between 25-33 years old, marking the highest percentage of all ages in this study. In conclusion, we can conclude that TTV is prevalent among healthy blood donors, and that polymerase chain reaction (PCR) is an effective and most accurate method for detecting this virus.