A NEW RP-HPLC METHOD FOR CONTEMPORANEOUSLY DETERMINATION OF FLOXIN AND CEFIXIME IN PHARMACEUTICAL FORMULATIONS

Abstract

The aim of the study was to develop and validate high performance liquid chromatography (HPLC) assay for the simultaneous determination of floxin and cefixiein in multicomponent tablet dosage form. Floxin is a fluoro quinolone subsidiary. Synthetically, it is(±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido-[1,2,3-de]-1,4- benzoxazine-6-carboxylicacid.It is primarily utilized as antibacterial for the management of urinary tract contamination, explicitly spreader illnesses. Floxin is utilized in the management of urinary tract, prostate, skin, urinary and respiratory tract contaminations. It is likewise used to treat certain explicitly transmitted ailments and is additionally utilized as an antibacterial operator in the treatment of diseases brought about by extensive scope of both Gram-positive and Gramnegative microscopic organisms. The method was validated with respect to specificity, precision, accuracy and linearity. Due to its simplicity and accuracy, the assay method is suitable for routine analysis of multi-component tablet formulation.