Hepatoprotective Activity Of Leaf Extracts From Tamarix Dioica Against Paracetamol Induced Hepatotoxicity In Swiss Albino Mices: A Systemic Review

Abstract

Paracetamol (acetaminophen) is widely used as an analgesic and antipyretic drug, but overdose can cause severe hepatotoxicity due to the formation of a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI), leading to oxidative stress and liver injury. The increasing prevalence of drug-induced liver damage has intensified the search for hepatoprotective agents from natural sources. Tamarix dioica, a halophytic shrub traditionally used in folk medicine, has shown promising hepatoprotective potential in recent experimental studies, particularly in murine models. This review summarizes and critically evaluates existing experimental data on the hepatoprotective effects of Tamarix dioica leaf extracts, with a focus on paracetamol-induced hepatotoxicity in Swiss albino mice. Mechanisms of action are explored, including antioxidant activity, enzyme normalization, and histopathological recovery. This review highlights Tamarix dioica as a potential natural therapeutic candidate for the prevention and treatment of drug-induced liver injury, warranting further investigation through clinical studies.