Study Of Serum Uric Acid In Type-2 Diabetes Mellitus (T2DM)

Abstract

Introduction:
Diabetes mellitus type-2 (T2DM) also known as non-insulin dependent diabetes mellitus is a metabolic disease characterized by hyperglycemia. Obesity and oxidative stress are the major contributing factor for diabetes mellitus, which are associated with high uric acid level.
Aim: - The aim of our study is to assess the serum uric acid level in type-2 diabetes mellitus to reduce the risk of renal failure, cardiovascular disease and other complication.
Materials and Methods: - This retrospective study, done at Department of Biochemistry and Shri Mehant Indresh Hospital, Shri Guru Ram Rai Institute of Medical and Health Sciences, Patel Nagar, Dehradun, from 2024-2025. The study included 100 Diabetic and 100 healthy control subjects.
Result: - In this present study serum uric acid level significantly elevated in diabetic group as compared to healthy control group. The mean Fasting blood sugar level was higher in diabetic group (201.09 ± 60.25mg/dl) than in healthy control (100.11± 9.51 mg/dl). The mean postprandial blood sugar level was higher in diabetic group (270.66±56.37 mg/dl) than in healthy control (132.06±24.51mg/dl). The mean uric acid level was also higher in diabetic group (8.40± 2.80mg/dl) than in healthy controls (5.04 ± 1.81mg/dl) (P value <0.0001)
Conclusion: - The study revealed that serum uric acid concentrations were significantly elevated in diabetic patients compared to healthy controls. We also found a Significant positive correlation between fasting, postprandial blood sugar and uric acid in type-2 diabetes mellitus.