Formulation And Evaluation Of Fast Dissolving Tablet Of Acarbose Using Effervescent Disintegrants

Abstract

Objective: The objective of the present study was to address the issue of dysphagia, which is commonly observed across all age groups, by developing an alternative oral dosage form that enhances patient compliance. Fast-dissolving tablets (FDTs) of Acarbose were formulated with the goal of providing a more patient-friendly administration route compared to conventional solid dosage forms.

Method: In the present work, fast dissolving tablets of Acarbose were designed with a view to enhancing patient compliance by the direct compression method. In the direct compression method, Sodium Bicarbonate and Tartaric acid as an Effervescent mixture were used along with directly compressible Mannitol and Maltodextrin to enhance mouth feel.

Results: The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, water absorption ratio, and in vitro dispersion time. Short-term stability (250C/ 60% RH and 40°C/ 75% RH for 3 months) and drug-excipient interaction study (IR spectroscopy). Among all the formulations, the formulation prepared by using 80 mg Sodium bicarbonate and 40 mg Tartaric acid was found to have the minimum dispersion time (48 - 54 s)

Conclusion: The study successfully developed a fast-dissolving tablet formulation of Acarbose that offers rapid dispersion and improved patient compliance. The use of effervescent agents and taste-enhancing excipients proved effective, and the optimized formulation was found to be stable under short-term storage conditions. This approach presents a viable alternative for patients experiencing difficulty swallowing traditional oral dosage forms.