In Silico Admet Profiling And Drug-Likeness Assessment Of Phytocompounds From Athiyadhi Kashayam: A Virtual Screening Approach

Abstract

Traditional Siddha system of medicine has its own uniqueness. It is integrated into our day today life style. In India Diabetes mellitus is a serious condition that affects most of the population and leads to mortality, and it may increases massively by 2025. Athiyadhi Kashayam, a traditional Siddha polyherbal formulation, is widely used for its therapeutic benefits in treating diabetes mellitus. It is composed of Ficus racemosa, Cassia auriculata, Cassia fistula, Syzygium cumini, Salacia reticulata. This particular formulation was retrieved from Mega Nivarana Bodini Ennum Neerizhivu Maruthuvam. The above mentioned ingredientsare known for their antioxidant potential and anti-diabetic property. In the current study, virtual screening and in silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions were employed using the pkCSM module to assess the pharmacokinetic behaviour, toxicity, and drug-likeness of selected phytoconstituents. Among the compounds tested, Kaempferol and Ellagic acid demonstrated favourable ADMET profiles and drug-likeness properties, highlighting their potential as lead compounds. The comprehensive evaluation offers insights into the formulation’s pharmacological efficacy and safety, providing a rationale for further preclinical validation.