Formation Of Pancreas Secretory Activity And Enzyme Homeostasis In Postnatal Ontogenesis

Abstract

Experiments were performed on white, outbred rats of different ages (15 days, 1 month, 2 months, 3 months and 4 months). After reaching a certain age, they were decapitated under anesthesia and their pancreas was removed.

During decapitation, blood was collected. Amylolytic and lipolytic activity was determined in the filtrate and blood serum, the activity of these enzymes was studied in postnatal ontogeny in the pancreas and blood. Amylase and lipase enzymes were fully formed in the pancreas of rats at the age of 4 months, and in the blood at 3-4 months of age. These changes in the amylolytic and lipolytic activities in the pancreatic tissue and blood of rats depend on the change in their feeding pattern (transition from lactotroph to mixed diet), increased energy expenditure, and changes in the enteropancreatic recirculation of these enzymes.