Development And Characterization Of Pharmacosomal Nanoemulsion-Based Etodolac Gel For Topical Anti-Inflammatory Therapy

Abstract

For the most part, our studies center on developing new topical nanoemulsions for etodolac to get around its drawbacks.   A combination of ultrasonication and high shear homogenization is used to create etodolac nanoemulsions.The formulation components are optimized in a methodical manner employing a design of experiments approach. The modified formulation's zeta potential (ZP), polydispersity index (PDI), and droplet size (DS) were evaluated using the DLS method. To investigate the drug-excipient interactions, we used Fourier transform infrared spectroscopy (FTIR) analysis, and to investigate the surface topology, we employed electron microscopy.     Researchers also looked at permeability and in vitro release.   A rat model of carrageenan-induced paw edema was used to evaluate the effectiveness in reducing inflammation. A PDI of 0.141, a DS of 163.5 nm, and a ZP of 33.1 mV are the parameters of the ideal formulation. The in vitro release profile was evaluated as sustained release by employing a non-Fickian drug transport strategy. The coarse dispersions had a flux of 59.7 15.2 g/cm2 h, while the etodolac nanoemulsions had a flux of 165.7 11.7 g/cm2 h. At6,8, and 24 hours, the inhibition of edema improved by 13.4%, 36.5%, and 50.65%, respectively. The findings indicate that nanoemulsions are an excellent vehicle for the topical administration of etodolac.