Synthesis, in silico ADMET study and anti-oxidant action of novel phenyl azetidin-2-one derivatives

Abstract

In this investigation, we have synthesized novel azetidin-2-one derivatives, 6a-j and performed the in silico ADMET study and in vitro antioxidant study of the molecules. The synthesis of the target compounds was confirmed by spectral analysis. Four compounds6c, 6d, 6h and 6a were found to possess good antioxidant action. These compounds inhibited DPPH radical by 78%, 64%, 60% and 45% respectively. All studied compounds are expected to exhibit high absorption, strong permeability, and bioavailability, resulting in a favourable drug-likeness profile. The results of our study led us to conclude that phenyl-2-azetidinone nucleus could be easily synthesized and can be computationally optimized to obtain good anti-oxidant compounds.