Formulation And Characterization Of Novel Formulation Of Terpineol

Abstract

The encapsulation of essential oils into nanocarriers offers a promising strategy to enhance their stability, bioavailability, and controlled release properties for pharmaceutical, cosmetic, and food applications. This study focuses on the formulation and evaluation of essential oil nanocapsules using a suitable polymeric or lipid-based encapsulation system. Essential oils were selected for their known therapeutic properties, and nanocapsules were prepared using techniques such as nanoprecipitation or emulsification–solvent evaporation. The formulated nanocapsules were characterized in terms of particle size, zeta potential, encapsulation efficiency, morphology, and in vitro release profile. Stability studies and bioactivity assessments, including antimicrobial and antioxidant assays, were also conducted. scanning electron microscopy (SEM) and transmission electron microscopy (TEM) for morphological assessment, and Fourier-transform infrared spectroscopy (FTIR) to investigate chemical interactions. Encapsulation efficiency and drug loading capacity were determined through UV-Vis spectroscopy or HPLC, while in vitro release studies were conducted using dialysis methods. Additionally, thermal stability was assessed via differential scanning calorimetry (DSC), and bioactivity assays including antioxidant and antimicrobial tests were performed to evaluate functional efficacy. The results demonstrate that nanocapsulation significantly enhances the physicochemical stability and biological efficacy of essential oils, suggesting their potential in targeted delivery and extended shelf life in various applications. They are employed in areas such as genetic engineering, cosmetics, household cleaning products, and wastewater treatment. Furthermore, they play a crucial role in the delivery of adhesive agents, and have promising uses in cancer therapy and neuroprotective treatments due to their targeted delivery and controlled release capabilities.