Role Of Leucine Rich Alpha 2 Glycoprotein 1 In Patients With Type 2 Diabetes Mellitus

Abstract

Background: Elevated levels of plasma Leucine rich apha-2 glycoprotein1(LRG1) which is associated with   development  and  progression of type 2 diabetes mellitus  where  it is increased in patients with (T2DM) and also increased during complications of (T2DM)  such  as: retinopathy, neuropathy and kidney diseases.

Objective: The aim of the present study is to find the   relationship between   leucine   rich   alpha -2 glycoprotein1 (LRG1) with occurrences and development of Type 2 diabetes mellitus (T2DM).

Method: The current study is a case-control study conducted on 90 Iraqi   participants for average   age (20-70) years during the period between (November-2024) to (March -2025), participants from (Imam Hassan Center for Endocrinology and Diabetes) in (Holy Karbala Governorate  -Iraq). This study including 90 participants divided into two groups:  60   patients with type 2 diabetes mellitus (T2DM) and 30 healthy control. Serum levels of (LRG1) was measured by using ELISA Kit.

Results:  (LRG1) levels was significantly elevated in patients group with type 2 diabetes       mellitus (T2DM) compered to control group. (LRG1) demonstrated an AUC of  (0.853) with (P < 0.001) and (sensitivity 78% , specificity 70%) at  a cut off of  (0.76) ug/ml in the current study.

Conclusion: (LRG1) is valuable biomarker in diagnosing and differentiation of patients with type 2 diabetes mellitus (T2DM) and also it is considered as a risk factor for  type2 diabetes mellitus (T2DM) in this study.