The Impact Of Tnf- Α , Il17 , Fsh And Lh On Male Infertility In Al-Najaf Province

Abstract

Male infertility is one of more common disease around the world , there are many factor affect on infertility or subfertility such as hormonal imbalance , inflamatory and proinflamatory cytokine , tumor necrosis factor alpha  , Interleukin -17, FSH  and LH associated with impaired spermatogenesis . the aim of this study to  investigation  TNF-α , IL-17,FSH and LH  in serum for  male infertility and compare with fertility as well as the association with semen parameter . A case control study involved 60 infertility group and 30 fertility group the blood serum was collected and measured using ELIZA device while semen parameter measuring according to WHO 2021 guide line . The infertility men show high level in proinflamatory cytokine  TNF-α and IL-17 compared to fertility group and decrees the level of gonadotropic hormone in infertility group compared with fertility group  , age ,ejaculate volume ,concentration ,motility and morphology found associated with elevated of inflammatory cytokine  as well as hormonal imbalance. In conclusion chronic immunity inflammation and hormonal disturbance affect on fertility so the TNF-α , IL-17,LH and FSH can regard as a biomarker for monitor and treatment male infertility.