The Role Of Inhibin B, Kisspeptein ,Testosterone And Vitamin E In Male Infertility : A Study In AL-Najaf Provence

Abstract

infertility in male is affected  by many factor influenced by hormonal imbalance , environmental condition , diet ,smoking and genetic , one  of these  factor is hormone  kisspeptein ,  inhibin B ,testosterone hormone and vitamin E play critical role in regulating spermatogenesis and oxidative stress ,the aim of this study is investigate the association between serum kisspeptein , inhibin B ,testosterone , vitamin E  level in fertility and non fertile group also to evaluate semen parameter such as concentration ,motility and morphology . this study involved 60 case infertility men group  and 30 case fertile men group  as control in AL- najaf province  the level of all markers measure by using ELIZA device while  semen parameter conducted according to WHO 2021 . The result in this study demonstrated reduced the level of both inhibin B , kisspeptein and testosterone in infertile group compared to fertile group (P=< 0.005 ) ,and elevated level of vitamin E in infertile group  also the markers show positive correlated with semen parameter such as  concentration ,morphology and motility in conclusion Inhibin –B , kisspeptein and testosterone are used as a marker in investigation infertility man  and impaired semen parameter while Vitamin E no correlation with fertility .