Development And Characterization Nano-Conjugates Of Folic Acid Modified Gamma-Oryzanol Targeted Therapy For Rheumatoid Arthritis

Abstract

To improve the effectiveness of drug delivery in the treatment of RA, a variety of adaptable nanocarriers with modifiable physicochemical characteristics, adjustable drug release profiles, or active targeting capabilities were created. The carbon nanotube is one of the most well-known nanomaterials with a high surface area, which is utilized to illustrate a consistent drug release. Nevertheless, researchers have obtained encouraging outcomes in targeted delivery for arthritis illness utilizing either single-walled carbon nanotubes (SWCNT) or multi-walled carbon nanotubes (MWCNT). This viewpoint employs functionalized carbon nanotubes to improve medication accuracy, control drug release, and reduce adverse side effects in order to create a targeted therapy for rheumatoid arthritis. In this study, gamma oryzanol (GOZ) was modified with folic acid (FA) to prepare FA-f-MWCNTs-GOZ nano-conjugate of multiwalled carbon nanotubes. The stability, sustained release, anti-inflammatory effect, andtherapeutic impact were evaluated using in vitro tests. FA-f-MWCNTs-GOZ nano-conjugate demonstrated high stability, prolonged release, and anti-inflammatory properties. A variety of adaptable nanocarriers with tailorable drug release patterns, regulated physicochemical characteristics, or active targeting capabilities were created to improve medication delivery efficiency in the treatment of RA. Carbon nanotubes are among the most well-known nanomaterials with a large surface area that are used to show a consistent release of medications. However, researchers have obtained encouraging results using either single-walled carbon nanotubes (SWCNT) or multi-walled carbon nanotubes (MWCNT) in targeted delivery for arthritis. This method uses functionalized carbon nanotubes to deliver medicines with greater precision, control drug release, and reduce undesirable side effects.to create a targeted therapy for rheumatoid arthritis. Approaches. In this work, folic acid was created by modifying gamma oryzanol (GOZ) with folic acid (FA). In vitro experiments were used to assess the therapeutic, anti-inflammatory, sustained release, and stability of FA-GOZ. The findings revealed that FA-GOZ had a high level of stability, sustained release, and anti-inflammatory activity.