Antidiabetic Activity Of Bioflavonoid Curcumin On Alloxan Induced Diabetic Rats
DOI:
https://doi.org/10.64252/3eff1h37Keywords:
Curcumin, alloxan-induced diabetes, hypoglycemic effect, oxidative stress, antioxidant and flavonoidsAbstract
Aim:The aim of the present study was the evaluation of antidiabetic effect by curcuin in alloxan-induced diabetes rats.
Methods: A single dosage of 120 mg/kg of alloxan was injected to induce diabetes, which was validated 72 hours later. Curcumin (40 and 80 mg/kg; oral) was given every day for three weeks. When compared to control animals, the group of animals given alloxan experienced a marked rise in hyperglycemia.
Results: The protective impact of curcumin was enhanced at both the lower and higher doses (p < 0.05; p < 0.01), and both doses (40 and 80 mg/kg) reduced the increases of blood glucose in diabetic rats. However, animals given alloxan experienced elevated hyperglycemia.
Conclusion: We found that the antioxidative/chelatory qualities of the flavonoids may be linked to their protective impact in experimental diabetes mellitus. It might possibly contribute to flavonoids' hypoglycemic action.
