Estimating The Levels Of (Coenzyme Q10) In Patients With Type II Diabetes Mellitus
DOI:
https://doi.org/10.64252/79ms6k61Abstract
Type II Diabetes Mellitus (T2DM) and its precursor, pre-diabetes, are characterized by chronic oxidative stress and metabolic dysfunction. Nuclear Factor Erythroid 2–Related Factor 2 (Nrf2), a master regulator of antioxidant defenses, are crucial in cellular protection. This study aimed to estimate the levels of serum Nrf2 in T2DM patients, pre-diabetic individuals, and healthy controls, and to evaluate their diagnostic potential. In order to obtain the necessary ethical permits, the team of the ethical committee, the faculty of medicine, the university of Karbala, and the Karbala Health Directorates / Karbala-Iraq contributed their support.
This study’s aim was to assess the CoenzymeQ10 levels in sera of (T2DM) patients ,pre diabetic and healthy control subjects
Methods: A case-control study in Iraq, involving 46 type 2 diabetes patients, 30 control volunteers, and 12 prediabetic volunteers aged 20-75, was conducted from September 2024 to July 2025.
ResultsThe study analyzed glycated hemoglobin (HbA1c) and lipid levels in diabetic and prediabetic groups, with diabetic and prediabetic groups showing typical glycemic and dyslipidemia patterns. Serum CoQ10 levels showed a significant decline from healthy controls (mean 1.6 U/L) to the prediabetic group (mean 0.89 U/L), with the lowest in diabetic patients(mean 0.38 U/L). ROC curve analysis showed excellent diagnostic accuracy of CoQ10, with an AUC of 0.9724 (p<0.0001) ,optimal lower limit of <1.275 U/L.for diabetic patients and 0.9013 (p < 0.0001), optimal lower limit of < 1.120 U/L.for prediabetes. A significant positive correlation was found between CoQ10 levels both diabetic (r = 0.4, p = 0.05) and prediabetic (r = 0.65, p = 0.001) .
Conclusion: Serum CoQ10 levels decrease with metabolic dysregulation, serving as an accurate biomarker for diagnosing pre-diabetes and Type II Diabetes Mellitus, highlighting its potential as a non-invasive tool for glucose metabolism monitoring.
