Hematological Parameters In Patients With Inflammatory Mucocutaneous Disorders- A Clinical Retrospective Study

Abstract

Background-

The chronic mucocutaneous diseases are systemic autoimmune conditions capable of impacting the oral cavity, often exhibiting oral manifestations as an initial symptom for many patients like the OLP, Pemphigus vulgaris, SLE. The chronic mucocutaneous diseases have a inflammatory component.

Aim-

The study aimed to evaluate and compare the hematological profile of the various mucocutaneous diseases with healthy individuals.

 Materials and Methods-

For the study, A total of 150 medical records were included after meeting the inclusion criteria. Out of which 100 were clinically proven various mucocutaneous diseases (Oral Lichen Planus, Lichenoid Reaction and Pemphigus Vulgaris) and 50 were healthy individuals. The Complete laboratory data like the Red blood cells counts ,Hemoglobin ,Total count ,Differential counts like neutrophil count , lymphocyte count of these patients were included  .The NLR was calculated from neutrophil and lymphocyte counts . The obtained data was tabulated and Statistical analysis like independent T-test and pearson chi-square test was conducted using IBM SPSS statistics version 23 (IBM Corp., Armonk, NY).

Results-

There is a significant difference between the four groups in the Hb, TC, Differential counts like the neutrophils, and lymphocyte counts ,NLR (p <0.05).There is reduction in the HB% and whereas increase in the neutrophil counts , lymphocyte counts and thereby increase in the NLR ratio. When compared between the OLP and pemphigus groups there was significant difference between the parameters.

Conclusion-

The present study demonstrated a significant difference in Neutrophil-lymphocyte ratio in the mucocutaneous diseases when compared to that of healthy individuals. This NLR can be used as a inflammatory biomarker for chronic diseases and also to assess the prognosis of the disease .