Investigation Of The Antidiabetic Potential Of A Polyherbal Formulation In Streptozotocin-Induced Diabetic Rats

Abstract

Hyperglycemia due to decreased insulin production or insulin action, or both, characterizes diabetes mellitus, a chronic metabolic condition. The use of polyherbal formulations has recently garnered interest as a potential alternative to traditional methods of diabetes treatment because to their synergistic effects and lower toxicity. A new polyherbal formulation of carefully chosen medicinal herbs with a history of usage in diabetes treatment is the subject of this investigation into its antidiabetic properties. The polyherbal formulation was tested on diabetic Wistar rats that had been induced with streptozotocin (STZ). Animals were chosen for the investigation if their fasting blood glucose levels were greater than 250 mg/dL, and diabetes was induced by injecting 55 mg/kg of STZ intraperitoneally. Over the course of 28 days, the diabetic rats were given varying dosages of the polyherbal formulation orally. Blood sugar levels, insulin levels, lipid profiles, and indicators of oxidative stress were among the standard biochemical measures assessed. Additionally, pancreatic tissue was examined histopathologically. In comparison to diabetic control rats, the polyherbal formulation considerably decreased FBG levels and improved serum insulin levels (p < 0.05). In addition to reducing oxidative stress and normalizing lipid profile parameters, the formulation treatment also increased activity of antioxidant enzymes like catalase and superoxide dismutase (SOD) and decreased malondialdehyde (MDA) levels. Researchers found that the treated groups' pancreatic islet architecture had been restored by histopathological investigation. The polyherbal formulation probably has antioxidant and pancreatic β-cell protecting actions, since it showed considerable antidiabetic activity in rats with diabetes induced by STZ. These results provide credence to the idea that the formulation could be useful as an auxiliary treatment in the treatment of diabetes mellitus.