Facile Synthesis Of Cnps From Mesosphaerum Sauveolens And Its Antimicrobial, Antioxidant And Anticancer Property

Abstract

Carbon nanoparticles are widely used in biological application due to their biocompatibility. However, the characters of CNPs depends upon the method of synthesis and origin of the material. In this study, CNPs are synthesized from an aromatic, medicinal plant Mesosphaerumsauveolens through open incineration method in the form of biosoot. The biosoot thus collected were characterized for their nanoproperties using DLS, SEM, XRD, FTIR and BET. Further their biological activities like antimicrobial property were evaluated using few bacteria and fungal species. The antioxidant property of the CNPs of Mesosphaerumsaueolens was evaluated using DPPH free radical. The anticancer ability was evaluated against the breast cancer cell line MFC-7. The study revealed the size of the biosoot of Mesosphaerumsauveolens falls between 121 to 289nm; 344nm to 818nm and 2313nm to 5500nm when studied through DLS, SEM revealed the size range between 30 to 50nm, The XRD revealed the nature of CNPs as both crystalline and amorphous in nature. FTIR revealed the presence of alkynes, Phosphines, Alkyl mercaptans, Aromatic hydrocarbon and secondary amines as its associated compounds. BET revealed the total pore volume as 2.5388^-02cc/gm and the mean pore size as 0.8nm. The antimicrobial study revealed that CNPs of Mesosphaerumsauveolens controlled all the bacteria studied except that of Pseudomonas aeruginosa and between the fungi, Aspergilus flavus was controlled when compared to Aspergillus niger. The EC₅₀ value recorded for DPPH was at 32µg. The LD₅₀ dosage for anticancer actvity against the breast cancer cell line recorded was 69.77µg. The study revealed the easiest method to synthesis CNPs from the medicinal plant. The synthesized CNPs of Mesosphaerumsauveolens can act as a potential antimicrobial, antioxidant and anticancer agent after proper study for their toxicity. These CNPs of Mesosphaerumsauveolens can be successfully used in cosmetic and pharmaceutical industry as an amendment to topical creams.