Oxidative Stress Markers And Antioxidant Vitamins In Women After Menopause With Chronic Heart Disease

Abstract

Background: Due in part to hormonal changes raising oxidative stress, postmenopausal women are more likely to develop chronic heart disease (CHD). Developing preventative plans depends on a knowledge of the function of oxidative stress indicators and antioxidant vitamins.

aim: This study is to assess the degrees of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and vitamins A and C in postmenopausal women with chronic heart disease.

Methods: 90 postmenopausal women (60 patients with CHD and 30 healthy controls) aged 50–60 years were subject to a case-control study. ELISA was used to examine blood samples for MDA, SOD, GPx, vitamin A and C concentrations. Duncan's multiple range test and ANOVA were used in statistical analysis.

Results: MDA levels were significantly higher in CHD patients (5.67 ± 0.61 µmol/L) compared to controls (2.66 ± 0.34 µmol/L, p < 0.05). Antioxidant enzymes GSH-Px and SOD were significantly lower in patients (0.81 ± 0.44 and 21.92 ± 7.07 U/mL respectively) than controls (2.54 ± 1.03 and 36.82 ± 9.68 U/mL, p < 0.05). In addition, significantly decreased in the levels of vitamin A and C were observed. Conclusion The study shows that postmenopausal women with CHD with higher oxidative stress and lower antioxidant defenses have a significant relationship. These results confirm the importance of frequent monitoring of oxidative stress indicators in this group and of antioxidant-based preventative policies.