Effects Of Osteoporosis Induced By Bilateral Ovariectomy On Estrogen Receptor Alpha And Beta Gene Expression And Hormonal Profiles In Rabbits

Abstract

Osteoporosis is a serious health issue for older postmenopausal women. For the majority of postmenopausal women with osteoporosis, bone loss is associated with estrogen deficiency. This study aimed to investigate the role of estrogen α and β receptors in osteoporosis development in ovariectomized rabbits, with a focus on their correlation with bone loss. Twenty female rabbits with ovariectomies were split into two groups at random: the ovariectomized group (OVX group) and the control group. X-rays of the control and OVX groups were taken six weeks post-ovariectomy. In OVX models, the X-ray results showed a marked reduction in femoral fragility and bone density. Additionally, the results of gene expression show that alpha and beta estrogen receptors "Downregulation of ESR1/ERα in ovariectomized rabbits.: Research on postmenopausal individuals or animal models undergoing ovariectomies has demonstrated that estrogen deprivation may result in a decrease in ERα expression in bone cells. "However, ovariectomy led to upregulation of beta estrogen receptors (ESR2/ERβ) in bone cells, likely due to altered hormonal signals post-osteoporosis."