Evaluation Of Wound Healing Activity Of Echinochloa Frumentacea Seeds

Abstract

A wound is a loss or breakage of the skin’s epithelial cells caused by sub-lethal trauma, leading to disruption of their anatomic and functional continuity. Wound-healing is a process of regaining the integrity of skin cell structures that are affected by microbial or bacterial inflammation and oxidative stress. Echinochloa frumentacea is known for its proven antioxidant, anti-inflammatory, antibacterial, and free radical scavenging properties, but there is no detailed scientific data available regarding its wound-healing activity. The present study was designed to evaluate the wound-healing activity of Echinochloa frumentacea seeds on Wistar albino rats. The wound healing efficacy of the methanolic seed extract of Echinochloa frumentacea was evaluated in the excision wound model at 200mg and 300mg concentrations and compared with the standard drug. The parameters studied include the wound contraction rate and the complete period of epithelialization. The methanolic seed extract of Echinochloa frumentacea was found to possess significant wound healing activity against the control and standard groups, which was evidenced by a decrease in the period of epithelialization and an increase in the rate of wound contraction. As Echinochloa frumentacea seeds have the potential to heal external wounds, it is hypothesized that they may also promote internal wound healing and could serve as a natural alternative in wound management.