Evaluation of Anti-Urolithiasis activity of Eleusine coracana seeds extract by in-vitro Study

Abstract

Urolithiasis is very common now a days. Eleusine Coracana is a millet, capable to show lots of pharmacological activities like antibacterial activity, anti-oxidant, anti-diabetic, Immunomodulatory activity. It is known as Eleusine Coracana and belongs to Poaceae family. It is cultivated in Garhwal region of Uttarakhand. It has consisted different chemical constituent like flavonoids, phenols, alkaloids, glycosides, phenolic compounds etc. Extraction of millet was done by Soxhlet apparatus. Anti-urolithiasis testing was done by the Aggregation and Nucleation assay method and check the effectiveness of plant extract by observing the dissolving of crystals of calcium oxalates in the stock solution of millet. It was observed that 40mg/ml was best for anti-urolithiasis activity of millet. By performing the phytochemical test, indicated the presence of glycosides, phenolic compounds, flavonoids, saponins, alkaloids etc. the absorbance of Eleusine Coracana was 620nm.