Harnessing Oleogels For Enhanced Topical Drug Delivery: Insights And Innovations

Abstract

Oleogels have garnered a lot of attention in pharmaceutical research as innovative topical carriers for antifungal medications due to their unique physicochemical properties and therapeutic potential. Oleogels, semi-solid systems designed by structuring oil with a gelling agent, offer a non-aqueous, biocompatible medium that enhances the solubility, stability, and bioavailability of lipophilic drugs. This study looks at the composition, characteristics, and applications of oleogels in the topical delivery of antifungal medications. The study highlights the significance of selecting the appropriate oils and gelling agents and how they impact the characteristics of medication release, skin penetration, and spreadability. Important formulation parameters like stability, rheological behavior, and drug-loading efficiency are investigated to optimize the efficacy of antifungal treatment.To evaluate the structural integrity and interaction between the drug and oleogel matrix, advanced characterisation methods such as scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) are used. Because they offer prolonged drug release, improved patient compliance, and less systemic adverse effects, oleogels offer a compelling substitute for traditional formulations. Additionally, their hydrophobic nature enhances shelf-life stability by guarding against microbial contamination. Recent developments are also included in the study, such as the use of natural oils and innovative gelling agents to produce formulations that are both economical and environmentally beneficial. The results open the door for further study into the therapeutic uses and commercialization of oleogels by highlighting their adaptability as a viable platform for the topical administration of antifungal drugs. To prove their effectiveness, more clinical research is required.