Formulation And Assessment Of Transdermal Patches Containing Sustained-Release Haloperidol For The Treatment Of Antipsychotic Illness
DOI:
https://doi.org/10.64252/cmyqhg98Keywords:
Transdermal patches, Haloperidol, Topical administration, Enhance permeation, Antipsychotic study.Abstract
Standard oral dosage formulations have a number of drawbacks, such as a tendency to cause rapid blood level spikes (both high and low) and poor bioavailability due to hepatic first pass metabolism. As a result, large and/or frequent dosage is required, which can be inconvenient and inappropriately costly. The transdermal drug delivery system (TDDS) was developed in order to enhance or improve such a character. By administering medications more precisely (i.e., site-specifically) inside the body, this approach will reduce the size and quantity of dosages while increasing therapeutic efficacy and safety. When it comes to treating conditions that require continuous care, TDDS is a great option. There are several advantages to topical delivery of medications over the more conventional oral dosage type. Due to the convenience of use and ability to improve patient compliance, the transdermal medication delivery system has become the standard remedy to this issue.