Synergistic Anticancer And Antioxidant Effects Of Eugenol And Baicalin

Abstract

This study investigates the anticancer and antioxidant potential of a novel phytochemical combination of eugenol, a natural compound extracted from cloves, and baicalin, a flavonoid from Scutellaria baicalensis. The synergistic interaction between eugenol and baicalin was found to exhibit moderate cytotoxicity against MCF-7 cell lines, with an IC50 value of 147.2 μM, suggesting potential anti-cancer properties. The combination also demonstrated potent antioxidant activity, comparable to quercetin, in DPPH and H2O2 scavenging assays. The results suggest that the eugenol-baicalin combination may have therapeutic applications in the prevention and treatment of oxidative stress-related diseases and cancer. Further studies are needed to fully elucidate the mechanisms of action and optimal dosing regimens. Overall, this study highlights the potential of combining natural compounds to create novel antioxidant and anti-cancer agents, and underscores the importance of continued research into the therapeutic properties of plant-derived compounds.