Docking, Ultrasonic Synthesis Of Some Heterocycle Compound Derived From N-Amino Phthalimide And Evaluation Of The Antibacterial Efficacy

Abstract

This research deals with the synthesis of some heterocyclic nitrogen compounds derived from N-amino phthalimide as a basic starting point using the ultrasound method which is considered a green chemistry method. Ultrasound synthesis technology was used to significantly accelerate the formation of these heterocyclic compounds compared with conventional methods. Meanwhile, docking simulations were conducted to evaluate their binding affinity to (coagulation factor X) using advanced computer programs. Their pharmacological potential was also evaluated using molecular docking studies. The results show that the prepared compounds have multiple promising pharmacological properties, making them strong candidates for drug development. The prepared compounds were characterized by various chemical and physical spectroscopic techniques, including FT-IR spectroscopy and nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR). Finally, the antibacterial activity of the compounds was studied on four Grampositive Staphylococcus aureus and bacillas and Gram-negative bacteria: E. coli and klebsiella in different concentration. Some compounds have shown activity against these bacteria.