The Effects Of Bioactive Compounds In Brown Algae (Pelvetiopsis Umitata) In Biochemical Changes Of Hyperglycemic Rats

Abstract

Type 2 diabetes mellitus (DM) is probably one of the oldest illnesses known to man. It was initially recorded in an Egyptian manuscript around three thousand years ago. Type 2 diabetes mellitus was characterized as a component of metabolic syndrome. Aim: present research aims to identify the effect of various amounts of brown algae (Pelvetiopsis Umitata) on biochemical alterations in hyperglycemic rats. Materials and Methods: Thirty-Six male Sprague Dawley rats have been separated into two main groups. The 1^st group consisted of normal rats (number =6) as the control (-). The 2^nd group (number =30) received an intraperitoneal injection of streptozotocin at a dose of seventy-five milligrams per kilograms, and those exhibiting blood glucose levels exceeding 250 milligrams per deciliter have been categorized as diabetic. Rats in this main group have been separated into five subgroups, (1) diabetic rats group as a control(+) (number =six) received basal diet without any treatment , (2) diabetic group (number = six) received basal diet +6% brown algae (3) diabetic group (number = six) received basal diet +9% brown algae,(4) diabetic group (number = six) received basal diet +14% brown algae &  (5)  diabetic group (number = six) received basal diet +18% brown algae. Following twenty-eight days, blood has been gathered, and serum was extracted to determine HbA1c, glucose, liver enzymes, kidney function and blood lipids. Results: Diabetic group fed on 18% brown algae had the minimal glucose concentration of any treated groups (diabetic) ever observed.  Also, the diabetic group of rats fed on 9% brown algae had the minimal levels of the treated group's (ALT, AST, ALP) enzymes and (total cholesterol, triglycerides), whereas the greatest value found for diabetes group rats nourished on 14% brown algae with a significant variance (P-value not more than 0.05).