Strategies And Approaches For Designing Of Pres-Coated Tablets For Chronodrug Delivery System

Abstract

Chronotherapeutic drug delivery system (CDDS) are innovative approaches designed to optimize the timing of drug release to align with the body's natural circadian rhythms. The physiological and biological states of the human body fluctuate significantly throughout the day, leading to variations in both the condition of diseases and the levels of drugs in the plasma. In the development of CDDS, press-coating technology-an inventive method of controlled drug release - has gained concern. By applying a coating around a drug core, this technique gives exact control over the drug's release profile. One special benefit of the press-coating process is that it guarantees the release of the active pharmaceutical ingredient (API) at specific times that correspond with the body's biological rhythms, particularly in conditions where symptoms vary over time (e.g., hypertension, asthma, arthritis).The press-coating method is a perfect match for chronotherapy because it uses compressive pressures to encapsulate the medicine in a multi-layer structure that can be made to react to different stimuli like pH, enzymes, or pressure. The coating's thickness and composition can be altered to create systems that can delay release, shield the medication from deterioration, and ensure targeted delivery. Better results will come from medications and treatments that are administered in alignment with the body's circadian rhythms. The methods of press-coating drug delivery and its production in chronotherapeutic drug delivery are the primary focus of this review. It analyses the different coating materials, the variables influencing press- coated delivery systems' performance and drug release. The possible advantages of these systems are also covered, including increased therapeutic efficacy, decreased side effects, and better patient compliance. In order to prepare the way for next-generation chronotherapeutic systems, the paper ends with future perspectives on combining press-coating technology with other modern drug delivery techniques.