“Design And Development Of Fresh Water Fish Scalp Derived Collagen/CMC Based Hydrogel For Treating Diabetic Foot Ulcer”

Abstract

As a useful food ingredient and food enhancer, collagen is highly prized. Usually, enzymes, microbes, and acid or alkali treatments are used to extract it. Collagen is extracted from the scale of tilapia fish. The yield of protein extraction was 2-3 times higher in extruded size samples. Compared to scale samples that were not extruded. Collagens are analysed using molecular weight distribution, FTIR, and a particle size analyser. If neglected, diabetic foot ulcers (DFU), a common and frequently incapacitating consequence of diabetes, can lead to lower limb amputations. Three-dimensional networks of hydrophilic polymers, known as hydrogel dressings, have been demonstrated to have outstanding fluid handling capabilities, low toxicity, and great biocompatibility. They can also absorb and hold huge amounts of water. Additionally, by facilitating angiogenesis, migration, and cell proliferation, hydrogels produce a moist wound environment that accelerates wound healing. As a result, hydrogels have shown promise as wound coverings to aid with DFU healing. During Preparation of Hydrogel we had prepared Solution A. Ca-Cs Solution (Collagen Solution+ Citric Acid),1-3% of Collagen and 0.4-0.6% of Citric Acid. Solution B. CMC solution 1-3% Of CMC (Carboxymethyl Cellulose), Solution C.  PVA solution  0.5-1% of PVA (Polyvinyl Alcohol), Solution D. nZnO+ Glycerol. Mixing of solution makes (CMC+PVA) Solution and CMC/PVA+ Ca-Cs Solution. Film and Thick layer hydrogel was prepared and analysed by using FTIR, SEM AND TEM.