Ceric(IV) Ammonium Nitrate Mediated Cross Dehydrogenative Coupling Of Ortho-Benzoylbenzofurans With Phosphites And Their Anti-Microbial Evaluation

Abstract

A low-cost cross-dehydrogenative coupling process of ortho-benzoylbenzofuran mediated by Ceric(IV) ammonium nitrate has been created. A simple one-pot method is used to create several ortho-benzoyl-3-phosphonylbenzofurans without the need for costly metals and other oxidants. Ceric(IV) ammonium nitrate converts organophosphorus compounds into phosphoryl radicals, which is followed by an electron transfer, electrophilic addition, and intermediate rearrangement, all of which result the required ortho-benzoyl-3-phosphonylbenzofuran. In moderate to good yields, a number of phosphorylated products with various functional groups were produced. Using the swab streak method, these compounds were tested for antibacterial and in vitro antifungal screening against four microorganisms. A few of the compounds exhibited remarkable activity.