Novelty Study Of Cholecystokinin And Its Relationship To Some Biochemical Parameters Before And After Gastric Sleeve Surgery For Both Sexes

Abstract

The study focused on the hormone cholecystokinin (CCK) and its relationship to obesity before and after gastric sleeve surgery. Forty-five samples were collected from obese patients of both sexes before surgery and served as a control group. They were followed up after surgery (group 1 after three months, group 2 after six months, and group 3 after nine months). Levels of CCK, CCKAR1, gastrin, ghrelin, leptin, GLP-1, GLP-2, amylase, lipase, ALPH, glucose, uric acid, lipid levels, and BMI were measured. The results showed significant improvements in the levels of biochemical variables in the patients, particularly after nine months. CCK levels showed a significant increase in their concentration after surgery and an effective interaction with other variables, reinforcing its preventive and therapeutic role in maintaining long-term physical health after gastric sleeve surgery, preventing complications, and combating obesity.