Study of the efficiency of Mn2O3 nanoparticles in the treatment of dysentery compared to metronidazole in vivo

Abstract

Entamoeba histolytica is a protozoan parasite of medical importance that causes gastroenteritis in a variety of vertebrate hosts. The current study aimed to isolate and purify the Entamoeba Spp. Parasite, infect experimental mice, and confirm the therapeutics efficacy of Manganese oxide nanoparticles on the Entamoeba histolytica parasite in vivo compared to the drug metronidazole for the treatment of amebiasis. The results of the present study demonstrated the efficiency of Manganese oxide nanoparticles in treating dysentery, evidenced by a significant reduction in the parasite's cysts in the stools of infected and treated mice. The therapeutic efficiency of manganese oxide nanoparticles at concentrations of 50, 75, and 100 µg/ml, as well as a combination of 37.5 µg/ml manganese oxide nanoparticles and 25 mg/kg metronidazole, on the tenth day was 72%, 89%, 100%, and 76%, respectively, while the therapeutic efficacy of 50 mg/kg metronidazole in mice was 71%, while the positive group was lying cysts. The higher therapeutic efficiency was to Manganese oxide nanoparticles at the concentration 100 which became zero on the tenth day.