Formulation, Optimization and In-vitro Evaluation of Balsalazide Nanospheres

Authors

  • Vaishali Pardhe Author
  • Ashish Jain Author

DOI:

https://doi.org/10.64252/hj8xk770

Keywords:

Nanospheres, Balsalazide, Eudragite RS, Eudragite L, Nanosystem.

Abstract

Nanospheres are the particles having the size range between 10-200 nm in diameter. Nanospheres can be amorphous or crystalline in nature and also, they have the ability to protect the drug from enzymatic and chemical degradation. It has been shown that the hydrophobic surfaces of these particles are highly susceptible to opsonization and clearance by the reticulo endothelial system. The aim was present work is focused on formulation and In-vitro evaluation for balsalazide nanosphere. Nanosphare containing Balsalazide were prepared using nanoprecipitation method. 200 mg of polymer (Eudragit RS: Eudragit L) was dissolve in 50 ml water. Drug was dissolve in 20 ml of methanol. micrographs that nanosphare drug loaded nanosphare and enteric polymer coated nanosphare were discrete, spherical or oval Balsalazide slightly rough surface. From the result aspect ratio of the nanosphares are 1.041. Percentage Assay and content uniformity of all batches was acceptable and came in to the range, except batch  F1. Drug entrapment efficiency of the formulations showed in the range of 90% to 96 %.

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Published

2025-06-18

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Articles

How to Cite

Formulation, Optimization and In-vitro Evaluation of Balsalazide Nanospheres. (2025). International Journal of Environmental Sciences, 11(11s), 656-668. https://doi.org/10.64252/hj8xk770