Assessment Of Corin Serum Level In Patients With Polycystic Ovary Syndrome A Cross-Sectional Study

Abstract

Background : Polycystic ovary syndrome is one of the most common metabolic disorder  in women with reproductive age group . With a prevalence rate of nearly 9% among women with  reproductive age. This study aimed to evaluate the Corin serum level in patients with  PCOS and its relation with insulin resistance and hyperandrogenism.  Methods: 60 patients with PCOS were screened to be suitable for participation in this study aged from 19 to 45 women they have been attended to outpatients clinic   as well as  30 healthy women  as a  control group   Serum  level of  insulin, testosterone and Corin were estimated, using an ELISA kit, as well as glucose ,FSH,LH and HbA1c have been calculated.

Results : the present study revealed that there is a significant differences in Corin serum level between  PCOS patients  and healthy control group. As well as   it showed a decrease in the ANP levels, although Corin is part of its function, which is to activate the ANP.  In addition the  study  demonstrated that  the Plasma Corin was directly correlated with BMI  and  LH/FSH ratio.

Conclusions: The results of this study emphasize the important  role of Corin serum level  in women with PCOS. Our data suggest that crculating Corin  reflect the metabolic abnormalities PCOS patients. Also revealed that there was a strong positive correlation between corin level and insulin resistance.