EVALUATION COLORECTAL CANCER ACTIVITY USING ALANGIUM SALVIIFOLIUM PHYTOCHEMICALS THOUGH INSILICO APPROACH

Abstract

The use of natural products to reduce the negative effects of marketed cancer medications is becoming more popular. This investigation utilized the components of Alangium salviifolium. Plants have alkaloids with anticancer effects, specifically beta-carboline harmaline and deoxytubulosine. CADD, a computational-based design technique, was employed to comprehend the anticancer properties of the alkaloids. The anticancer properties of the compounds were evaluated using the NPACT database, and the AutoDock program was used to test how well they bind to six different receptors. The results were displayed in Discovery Studio. These outcomes were assessed using Paclitaxel, a commonly marketed medication. Zinc oxide was added to the compounds to provide further advantages. Following adjustments, Discovery Studio displayed the findings of the molecular docking analysis conducted using the PyRx program. Beta-carboline harmaline must be validated in vitro for the pharmacokinetics study utilizing the pkCSM database.