Design Development And Evaluation Of Oral Suspension Of Antiemetic Drug

Abstract

The present study aimed to design, develop, and evaluate an oral suspension of an antiemetic drug, Domperidone, to improve its dissolution behavior, stability, and patient compliance. Preformulation studies were conducted to evaluate organoleptic properties, melting point, solubility, and drug–excipient compatibility using UV spectroscopy, DSC, and FTIR analysis. Placebo batches were initially prepared using various polymers, including sodium alginate, Carbopol 934P, xanthan gum, methyl cellulose, HPMC K4M, and gum acacia, to identify suitable suspending agents based on sedimentation volume and redispersibility. Drug-loaded flocculated suspensions were subsequently formulated and evaluated for sedimentation behavior, redispersibility, conductivity, pH, particle size, in-vitro dissolution, viscosity, and assay. Among all formulations, HPMC K4M–based suspension (FF5) demonstrated optimal physical stability, excellent redispersibility, acceptable viscosity, stable pH, uniform drug content, and superior in-vitro drug release. The study concludes that a stable and patient-friendly oral suspension of Domperidone can be successfully developed using appropriate polymeric suspending agents.