Role Of Orbital Arterial Color Doppler In Chronic Kidney Disease Patients With And Without Glaucoma

Abstract

Introduction: Glaucoma is disease characterized by optic nerve damage where vascular regulation is a strong impacting factor. This study investigates the role of Color Doppler Imaging in the early diagnosis and prediction of progression of glaucoma in patients with chronic kidney disease by analysing changes in ocular blood flow and vascular resistance.

Materials and methods: Prospective study done between 2024 and 2025 at RL Jalappa hospital. CDI assessed ocular blood flow in 50 CKD patients with glaucoma, 50 CKD patients without glaucoma, and 50 healthy controls. Measurements included peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) in the central retinal and posterior ciliary arteries. Data were compared across groups to detect significant differences and correlated with OCT results. Statistical analysis used ANOVA test

Results: In 50 CKD patients and 50 healthy controls, CDI revealed a 20% reduction in blood flow velocities and a 26% increase in vascular resistance in CKD patients with glaucoma. The Resistive Index (RI) increased by 30% in these patients, aligning with OCT and visual field findings.

Conclusion: CDI is a highly effective tool for early glaucoma detection and ongoing monitoring. It delivers critical insights into vascular changes that precede structural damage, facilitating prompt intervention and treatment approaches