The Role Cox -2 gene expression in uterine disorder

Abstract

Background: Uterine bleeding refers to the occurrence of lesions resembling endometrial glands and stroma located outside the uterus. The lesions may present as peritoneal lesions, superficial implants, cysts on the ovary, or deep infiltrating disease. Materials and Methods: Study was performed in the Women’s and Children’s hospital in Al-Muthanna, study specimens were divided into two groups, one for patients called a case and one for control were compared. The patients and control groups were with age ranged between (35-50) years all of them are female. Study was carried out on 60 patients with uterine bleeding and 30 apparently healthy subjects with a control group. All samples were collected in the period (March 2023 till November, 2023). In this study we investigated the correlation between COX-2 genes and uterine bleeding. We screened clinical samples of healthy and patient individuals suspected of uterine bleeding using q RT-PCR. Results: The results revealed a high association between COX-2 gene with the uterine bleeding disease. Conclusions: Our findings suggest that female patients with uterine bleeding in terms of gene regulation, there are genes contribute to the uterine bleeding disease such as COX-2. Several studies evident that those genes are considered as primary factors influence the conditions of uterine bleeding disease.