The Associations Between Hormones, Inflammatory Markers, And Blood Characteristics In Women With Abnormal Uterine Bleeding

Abstract

Background: Excessive or abnormal uterine bleeding AUB poses significant health challenges, specifically for perimenopausal women. Since AUB is a general clinical issue, identifying reliable biomarkers like COX-2 could address unmet medical requirements in identification and monitoring this problem.

Materials and Methods: Blood samples from 95 women (60 with abnormal uterine bleeding and 30 without AUB) were collected and examined for associations between commonly measured parameters, including hormone, antioxidant, interleukin-23, and cyclooxygenase concentrations, and abnormal uterine bleeding. The analyte concentrations were determined using ELISA assays.

Results: The current study display elevated levels of prolactin, interleukin-23, and cyclooxygenase in women with abnormal uterine bleeding compared to the control group. On the other hand, estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone levels were reduced.  Interleukin-23 and cyclooxygenase-2 levels were significantly higher in the abnormal uterine bleeding group across different age and BMI ranges compared to controls.

Conclusion: Elevated levels of IL-23 and COX in women suffering from abnormal uterine bleeding might serve as prospective biomarkers to identify underlying disorders associated with AUB.