Synthesis Of Novel Isoxazolidine Derivatives From Methional-Derived Nitrone: A Greener Approach

Abstract

The 1,3-dipolar cycloaddition reactions of methional-derived nitrones with various dipolarophiles have been extensively investigated to develop an efficient method for synthesizing structurally diverse isoxazolidines. These reactions demonstrated remarkable efficiency when conducted in green solvents, exhibiting significantly increased reaction rates and higher yields compared to those obtained with traditional organic solvents. The use of eco-friendly solvents not only improved the reaction outcomes but also had a profound impact on the stereoselectivity and regioselectivity of the reaction. This observation underscores the critical role of sustainable solvents in optimizing the synthesis of target compounds, in alignment with the principles of green chemistry. The synthesized isoxazolidines were subjected to rigorous structural characterization using a combination of spectroscopic and analytical techniques to determine their structures. This comprehensive analysis unequivocally confirmed the molecular structures of all newly synthesized compounds. Additionally, the potential practical applications of these novel isoxazolidines were explored through antibacterial activity assays. The evaluation revealed promising bioactivity profiles, suggesting that these compounds could serve as valuable leads for further development in medicinal chemistry applications. This finding opens new avenues for research into the therapeutic potential of isoxazolidines, particularly in the context of addressing bacterial infections and potentially contributing to ongoing efforts to combat antimicrobial resistance.