Design, Synthesis, And Spectral Characterization Of Chalcone-Based Pyrimidines

Abstract

Heterocyclic compounds such as pyrimidine, benzimidazole, and benzoxazole are aromatic in nature and are commonly found in a wide range of medicinal agents. Triazoles, which are five-membered heterocyclic rings containing three nitrogen atoms, are another important class of these compounds. The chemistry of heterocycles plays a vital role in everyday life—contributing significantly to the safety of food and beverages, and especially to the advancement of pharmaceutical science through the development of new therapeutic agents.

In the present study, a series of novel chalcones were synthesized using 2-chloro-7H-pyrrolo[2,3-d]pyrimidine and 1-(4-aminophenyl)ethenone, followed by condensation with various aldehydes. These chalcones were subsequently reacted with guanidine to yield a range of pyrimidine derivatives, labeled B1–B15. The synthesized compounds were characterized using techniques such as ¹H NMR, ¹³C NMR, IR and MASS spectrometry. Furthermore, all compounds were evaluated for their antimicrobial activity.