Synthesis, Characterization And Biological Activities Of Novel Methoxy Bezaldehyde Derivatives Of 4-Aminopyrrolo [2, 3-D] Pyrimidine

Abstract

The primary aims of this investigation encompassed the synthesis, characterization, and assessment of antibacterial and antifungal properties of novel pyrrolopyrimidine derivatives. The focus was directed towards the synthesis of methoxy-benzaldehyde derivatives of pyrrolopyrimidine. Spectroscopic techniques were employed for the characterization of synthesized compounds. The antimicrobial efficacy of the synthesized compounds was evaluated against various bacterial and yeast strains, including S. aureus MCC 2010, B. subtilis MCC 2010, E. coli MCC 2412, P. aeruginosa MCC 2080, C. albicans MCC 1439, and S. cerevisiae. Notable peaks were observed in FT(IR), ¹H and ¹³C NMR, and UV spectral analyses for all prepared compounds. Compounds E and g exhibited superior in vitro antibacterial and antifungal activity compared to streptomycin and fluconazole, considered as gold standards.