Diurnal Variation Of Intraocular Pressure And Central Corneal Thickness In Pseudoexfoliation Eyes: A Prospective Observational Study
DOI:
https://doi.org/10.64252/cxdf6a30Keywords:
Pseudoexfoliation syndrome, central corneal thickness, intraocular pressure, diurnal variation, glaucomaAbstract
Purpose: To evaluate the diurnal variation in intraocular pressure (IOP) and central corneal thickness (CCT) in pseudoexfoliation syndrome (PXS) eyes and assess their interrelationship.
Methods: This prospective observational study was conducted on 51 eyes diagnosed with PXS. IOP and CCT were measured at 8 AM, 11 AM, 2 PM, and 5 PM using Goldmann Applanation Tonometry and ultrasound pachymetry. Statistical analysis involved Friedman’s test and Spearman’s correlation.
Results: The mean age of patients was 68.96 ± 9.08 years. Mean IOP showed a decreasing trend: 17.75 mmHg at 8 AM to 16.82 mmHg at 5 PM. Mean CCT declined significantly from 524.22 µm to 515.51 µm (p < 0.001). A statistically significant negative correlation was found between CCT and IOP at all time points (ρ = –0.555 to –0.738, p < 0.001).
Conclusion: PXS eyes show significant diurnal reduction in CCT and an inverse relationship between IOP and CCT. These findings underscore the need to consider corneal thickness and time-of-day in IOP assessment for optimal glaucoma care.
