Thyroid Function Test In Sickle-Cell Disease
DOI:
https://doi.org/10.64252/q8wk1n16Keywords:
Sickle-cell anemia, Sickle-cell disease, Hypothyroidism, Thyroid function test.Abstract
Objective: This cross-sectional study aimed to evaluate the thyroid function (triiodothyronine [T3], thyroxine [T4], and thyroid-stimulating hormone [TSH] levels) in patients with sickle-cell disease (SCD).
Methods: This cross-sectional observational study was conducted at BRLSABVM Medical college,Rajnandgaon(Chhattisgarh).Patients included from Medicine and Paediatrics Department. Sixty-eight patients with SCD were enrolled for assessing their thyroid function. The reference ranges for serum T4 (4.5–12 µg/dL), serum T3 (60–200 ng/dL), and TSH (0.3–5.5 uIU/mL) were defined to evaluate the thyroid function.
Results: The average TSH, mean T4 level, and mean T3 level among the patients were 4.02, 4.67, and 74.15, respectively. The incidence rates of hypothyroidism and euthyroid status were 23.5% and 76.5%, respectively. While 9.59 g/dL was the mean hemoglobin level, 11–16 g/dL was observed in 42.6% of patients compared to <11 g/dL in 57.4% of patients. Patients within the age group of 14-25 years had a higher incidence of hypothyroidism (62.5%). The differences in hypothyroidism between males and females were statistically insignificant (68.8% vs. 31.2%, p = 0.11).
Conclusion: Patients with SCD had clinically significant reductions in T3 and T4 levels. In addition, higher levels of TSH and reductions in endogenous T3/T4 levels were observed in male patients. Overall, SCD was associated with a higher incidence of hypothyroidism.
