Protective Effect Of Ethanol Extract Of Dodonaea Viscosa Leaves Against Isoproterenol-Induced Myocardial Infarction

Abstract

Myocardial infarction (MI), a life-threatening disorder, arises from the imbalance between oxygen supply and myocardial demand. Several plant products are known to exhibit creditable medicinal properties for the treatment of heart ailments instead of allopathic medicine which causes severe adverse effects. The aim of the present study was to investigate the protective effects of Dodonaea viscosa leaves against isoproterenol-induced myocardial ischemia. Wistar strain rats were pretreated with Dodonaea viscosa leaves (500mg/kg body weight) for 20 days and then intoxicated with isoproterenol (ISO) (20mg/100g, i.p. for 2 consecutive days). Cardioprotection was assessed by estimating plasma  aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and total protein. Troponin T was estimated in serum, the levels of malonodialdehyde (MDA), reduced glutathione (GSH) were analyzed in plasma. In ISO-treated group, augmentation of cardiac markers in plasma and elevated lipid peroxidation where accompanied by decreased content of reduced glutathione in plasma. The prior administration of Dodonaea viscosa significantly  prevented the isoproterenol-induced alterations and restored the cardiac markers. These findings proved the cardioprotective activity of Dodonaea viscosa during isoproterenol-induced myocardial ischemia. The protective activity of Dodonaea viscosa due to the phytochemical present in the leaves.