Impact of Glycated Biomarkers, Antioxidant Parameters and TCF7L2 Gene Polymorphism in Type 2 Diabetes Mellitus Patients

Authors

  • Solaf Mohammed Saeed Author
  • Kalthum Asaaf Maulood Author

DOI:

https://doi.org/10.64252/07t2rc70

Keywords:

Type 2 DM, Adipsin, Aflatoxin M1, TCF7L2 gene polymorphism

Abstract

Type 2 diabetes mellitus (T2DM) is characterized by dysregulation of carbohydrate, lipid and protein metabolism, and results from impaired insulin secretion, insulin resistance or a combination of both. In this study, 60 sample male and female were collected from patient with T2DM and new case. The statistical analysis showed that the patients with T2DM, glycemic indices considerable increases, except HOMA-β and QUICKI demonstrated significant decreases, and elevated serum levels of these glycemic parameters elucidate their crucial role in the pathophysiology of T2DM. As far as we know this is the first study in Kurdistan region that investigate the effect of T2DM on aflatoxin m1 level, this parameter exhibited a non-significant increase in patients with Type 2 Diabetes Mellitus and is not regarded as a biomarker for the condition. The serum level of oxidative stress and GPX elevated but other antioxidant lowered in the T2DM group relative to the control group. TCF7L2 gene polymorphism was detected in genotype frequencies in Erbil T2DM patients. The heterozygous type of SNP rs7903146 (C > T) was the most frequent genotype. Gene polymorphisms of TCF7L2 (C > T) was considered as a risk factor for T2DM in Kurdish population.

Downloads

Download data is not yet available.

Downloads

Published

2025-09-24

Issue

Section

Articles

How to Cite

Impact of Glycated Biomarkers, Antioxidant Parameters and TCF7L2 Gene Polymorphism in Type 2 Diabetes Mellitus Patients . (2025). International Journal of Environmental Sciences, 3826-3843. https://doi.org/10.64252/07t2rc70